Apple's Cook fields his A-team before a wary Street

SAN FRANCISCO (Reuters) - Apple Inc Chief Executive Tim Cook's new go-to management team of mostly familiar faces failed to drum up much excitement on Wall Street, driving its shares to a three-month low on Wednesday.

The world's most valuable technology company, which had faced questions about a visionary-leadership vacuum following the death of Steve Jobs, on Monday stunned investors by announcing the ouster of chief mobile software architect Scott Forstall and retail chief John Browett -- the latter after six months on the job.

Cook gave most of Forstall's responsibilities to Macintosh software chief Craig Federighi, while some parts of the job went to Internet chief Eddy Cue and celebrated designer Jony Ive.

But the loss of the 15-year veteran and Jobs's confidant Forstall, and resurgent talk about internal conflicts, exacerbated uncertainty over whether Cook and his lieutenants have what it takes to devise and market the next ground-breaking, industry-disrupting product.

Apple shares ended the day down 1.4 percent at 595.32. They have shed a tenth of their value this month -- the biggest monthly loss since late 2008, and have headed south since touching an all-time high of $705 in September.

For investors, the management upheaval from a company that usually excels at delivering positive surprises represents the latest reason for unease about the future of a company now more valuable than almost any other company in the world.

Apple undershot analysts targets in its fiscal third quarter, the second straight disappointment. Its latest Maps software was met with widespread frustration and ridicule over glaring mistakes. Sources told Reuters that Forstall and Cook disagreed over the need to publicly apologize for its maps service embarrassment.

And this month, Apple entered the small-tablet market with its iPad mini, lagging Amazon.com Inc and Google Inc despite pioneering the tablet market in 2010.

Investor concerns now center around the demand, availability and profitability of new products, including the iPad mini set to hit stores on Friday.

"The sudden departure of Scott Forstall doesn't help," said Shaw Wu, an analyst with Sterne Agee. "Now there's some uncertainty in the management."

"There appears to be some infighting, post-Steve Jobs, and looks like Cook is putting his foot down and unifying the troops."

Apple declined to comment beyond Monday's announcement.

Against that backdrop, Cook's inner circle has some convincing to do. In the wake of Forstall's exit, iTunes maestro Eddy Cue -- dubbed "Mr Fixit", the sources say -- gets his second promotion in a year, taking on an expanded portfolio of all online services, including Siri and Maps.

The affable executive with a tough negotiating streak who, according to documents revealed in court, lobbied Jobs aggressively and finally convinced the late visionary about the need for a smaller-sized tablet, has become a central figure: a versatile problem-solver for the company.

Ive, the British-born award-winning designer credited with pushing the boundaries of engineering with the iPod and iPhone, now extends his skills into the software realm with the lead on user interface.

Marketing guru Schiller continues in his role, while career engineer Mansfield canceled his retirement to stay on and lead wireless and semiconductor teams. Then there's Federighi, the self-effacing software engineer who a source told Reuters joined Apple over Forstall's initial objections, and has the nickname "Hair Force One" on Game Center.

"With a large base of approximately 60,400 full-time employees, it would be easy to conclude that the departures are not important," said Keith Bachman, analyst with BMO Capital Markets. "However, we do believe the departures are a negative, since we think Mr. Forstall in particular added value to Apple."

TEAM COOK

Few would argue with Forstall's success in leading mobile software iOS and that he deserves a lot of credit for the sale of millions of iPhones and iPads.

But despite the success, his style and direction on the software were not without critics, inside and outside.

Forstall often clashed with other executives, said a person familiar with him, adding he sometimes tended to over-promise and under-deliver on features. Now, Federighi, Ive and Cue have the opportunity to develop the look, feel and engineering of the all-important software that runs iPhones and iPads.

Cue, who rose to prominence by building and fostering iTunes and the app store, has the tough job of fixing and improving Maps, unveiled with much fanfare by Forstall in June, but it was found full of missing information and wrongly marked sites.

The Duke University alum and Blue Devils basketball fan -- he has been seen courtside with players -- is deemed the right person to accomplish this, given his track record on fixing services and products that initially don't do well.

The 23-year veteran turned around the short-lived MobileMe storage service after revamping and wrapping it into the reasonably well-received iCloud offering.

"Eddy is certainly a person who gets thrown a lot of stuff to ‘go make it work' as he's very used to dealing with partners," said a person familiar with Cue. The person said Cue was suited to fixing Maps given the need to work with partners such as TomTom and business listings provider Yelp.

Cue's affable charm and years of dealing with entertainment companies may come in handy as he also tries to improve voice-enabled digital assistant Siri. He has climbed the ladder rapidly in the past five years and was promoted to senior vice president last September, shortly after Cook took over as CEO.

Both Cue and Cook will work more closely with Federighi, who spent a decade in enterprise software before rejoining Apple in 2009, taking over Mac software after the legendary Bertrand Serlet left the company in March last year

Federighi was instrumental in bringing popular mobile features such as notifications and Facebook integration onto the latest Mac operating system Mountain Lion, which was downloaded on 3 million machines in four days.

The former CTO of business software company Ariba, now part of SAP, worked with Jobs at NeXT Computer. Federighi is a visionary in software engineering and can be as good as Jobs in strategic decisions for the product he oversees, a person who has worked with him said.

His presentation skills have been called on of late, most recently at Apple annual developers' gathering in the summer.

Then there's Ive, deemed Apple's inspirational force. Among the iconic products he has worked on are multi-hued iMac computers, the iPod music player, the iPhone and the iPad.

Forstall's departure may free Ive of certain constraints, the sources said. His exit brought to the fore a fundamental design issue -- to do or not to do digital skeuomorphic designs. Skeuomorphic designs stay true to and mimic real-life objects, such as the bookshelf in the iBooks icon, green felt in its Game Center app icon, and an analog clock depicting the time.

Forstall, who will stay on as adviser to Cook for another year, strongly believed in these designs, but his philosophy was not shared by all. His chief dissenter was Ive, who is said to prefer a more open approach, which could mean a slightly different design direction on the icons.

"There is no one else who has that kind of (design) focus on the team," the person said of Ive. "He is critical for them."

(Additional reporting by Alistair Barr; Editing by Edwin Chan and Ken Wills)

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Disney unlikely to change ‘Star Wars’ brand

LOS ANGELES (AP) — Naysayers would have you believe Disney‘s purchase of Lucasfilm can only mean one thing: Bambi and Mickey Mouse are sure to appear in future “Star Wars” movies taking up lightsabers against the dark side of the Force.

Not so, say experts who’ve watched Disney’s recent acquisition strategy closely. If anything, The Walt Disney Co. has earned credibility with diehard fans by keeping its fingerprints off important film franchises like those produced by its Marvel Entertainment and Pixar divisions.

“They’ve been pretty clearly hands-off in terms of letting the creative minds of those companies do what they do best,” says Todd Juenger, an analyst with Bernstein Research. “Universally, people think they pulled it off.”

Though the Walt Disney Co. built its reputation on squeaky clean family entertainment, its brand today is multifaceted. Disney, of course, started as an animation studio in 1923 with characters such as Oswald the Lucky Rabbit, Steamboat Willie and Mickey Mouse. Over the years, the company ventured into live action movies, opened theme parks, launched a fleet of cruise ships and debuted shows on TV.

By way of acquisitions over the last few decades, it has ballooned into a company with $ 40.9 billion in annual revenue and a market value of $ 88 billion. Disney bought Capital Cities/ABC in 1995 for $ 19 billion, Pixar for $ 7.4 billion in 2006, Marvel for $ 4.2 billion in 2009 and this week, it said it will purchase Lucasfilm and the “Star Wars” franchise for $ 4.05 billion.

Disney’s acquisition of Marvel Entertainment in 2009 offers the best example of how it might treat Lucasfilm and the “Star Wars” universe.

Marvel was in the midst of a storyline that would span several films following the smash hit success of its first self-produced movie, “Iron Man,” in 2008. When Disney bought it a year later, it continued reading from the comic book giant’s playbook, releasing in subsequent years “Iron Man 2,” ”Thor,” ”Captain America” and then this year, “The Avengers,” which brought heroes from those movies together in one giant film that grossed $ 1.5 billion at the box office.

Now, “Avengers” director Joss Whedon is working on the sequel and developing a Marvel-based TV series for Disney-owned ABC.

Rick Marshall, a journalist and blogger who writes about the comic book and movie industries, was skeptical when Disney bought Marvel. But his doubts quickly melted when it was clear Disney wouldn’t taint the Marvel universe by getting too involved.

“I was the first one to say there’s going to be a Goofy-Wolverine crossover,” Marshall said. “We haven’t seen that… Disney was able to step away.”

Recent history ought to assuage “Star Wars” fans who fear the Disney empire. But that hasn’t stopped many of them from posting an array of video and pictorial mash-ups and jokes online as they poke fun at their darkest fears: Luke Skywalker staring into the distance at a mouse-eared sun and Darth Vader telling Donald Duck that he’s his father.

What Disney did with Marvel was merely amplify its presence in theme parks, stores and theaters, observers say.

Disney’s formula for success with Marvel was not to tamper with storylines, but to bring the existing franchise under its corporate umbrella.

Before it was acquired, Marvel paid Paramount Pictures a percentage of movie ticket sales to advertise its movies, make film prints and get them into theaters. Disney has those capabilities, so now that money doesn’t go out the door. Disney also has a worldwide network of staff that help put Marvel toys on store shelves, expanding their reach and saving the money that Marvel used to pay third-party merchandise middlemen.

Owning Marvel also gives Disney a steady flow of super hero cartoons for its pay TV channel, Disney XD. These kind of logistical savings allow Disney to profit from ownership while not interfering in the creative process.

“Marvel does seem like it’s running pretty independently and staying pretty close to its roots,” said Janney Capital Markets analyst Tony Wible.

Disney’s recent acquisitions have also filled gaps in its creative portfolio. CEO Bob Iger has said the company’s $ 7.4 billion purchase of Pixar in 2006 was partly an investment in talent and a way to “grow and improve Disney animation.” The deal brought John Lasseter, a former Disneyland employee, back into the fold as its chief creative officer of both Disney and Pixar’s animation studios.

The purchase of Marvel helped Disney add characters that would resonate with boys at a time when the company was becoming known more for princesses, fairies and its fictional teenage rock star Hannah Montana.

The “Star Wars” franchise fills a hole in Disney’s live-action portfolio, which suffered an embarrassing $ 200 million loss on the sci-fi flick “John Carter” earlier this year. The box-office bomb caused an executive shuffle at the studio that brought in former Warner Bros. president Alan Horn, who oversaw the hugely successful runs of “Harry Potter” and “The Dark Knight” movies.

It’s in Disney’s best interest to maintain the integrity of film franchises that come with a built-in fan base. Disney chief Iger has said the plan is for “Star Wars” live-action movies to replace others that may be in development, and to keep its production slate at a modest 7 to 10 movies per year.

“I think Disney’s intention is that it just doesn’t want to get in the way of a great asset,” said Morningstar analyst Michael Corty.

In a conference call explaining the acquisition, Iger told analysts that “Disney respects and understands, probably better than just about anyone else, the importance of iconic characters and what it takes to protect and leverage them effectively.”

When “Star Wars Episode 7″ hits theaters in 2015, millions of fans will surely hold Iger to his word.

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Sanofi draws fire over cost of MS drug Lemtrada

PARIS (Reuters) – Medical journal The Lancet warned that Sanofi‘s experimental multiple sclerosis drug Lemtrada may be too costly for patients and health insurers once it gets approved by regulators.

The journal, which published the encouraging results of two late-stage Lemtrada tests on Thursday, also criticized the drugmaker’s decision to withdraw leukemia therapy Campath, the same drug given at a different dosage, depriving MS patients who had been using it off-label.

In an editorial accompanying the test results, The Lancet voiced concerns that Lemtrada would be priced higher than current MS drugs on the market and said the discontinuation of Campath may mean patients who had used it for MS would not be able to continue their treatment.

The injectable drug, chemically known as alemtuzumab, was sold until September 2012 under the name Campath as treatment for leukemia and given more frequently at a higher dosage.

“There is concern that with a license for multiple sclerosis, the cost of alemtuzumab could rise and might become too expensive for many patients and health systems,” the editorial said.

Although Campath remains available free of charge to leukemia patients, Sanofi’s rare disease unit Genzyme pulled it off the market in September to prevent its unauthorized use as an MS drug.

Analysts said the move would allow the company to adjust the price to match that of rival MS drugs on the market.

A full course of Campath, which in 2011 had sales of $ 76 million, cost around $ 60,000 when given three times a week for up to 12 weeks, according to Genzyme.

Lemtrada, instead, is given at less than half the dose of Campath for 5 consecutive days and then again for 3 days a year later. Since the drug has yet to be approved, it remains unclear how much Sanofi will charge for it.

The drug, which works by resetting a person’s immune system, has shown in late-stage trials to be an effective treatment for MS patients who have failed to respond to other therapies.

It has also shown to benefit people not previously treated for the disease, suggesting it could be used as a first-line MS therapy.

But patients need regular monitoring for serious side effects that can include infections and autoimmune diseases.

“It’s important that the appropriate safety monitoring is in place for patients who are prescribed Lemtrada,” Genzyme’s head of MS, Bill Sibold, told Reuters, responding to questions about the Lancet editorial. “Until an approved risk-management program is established, we believe the use of Lemtrada should only occur in clinical trials.”

Lemtrada remains available to patients who are taking part in clinical tests.

Sibold declined to discuss pricing plans for Lemtrada, but said Genzyme has set up programs to make its approved drugs available to patients who cannot afford them. “With Lemtrada it would be no different,” he said.

DRUG FUNDING

But there are concerns that cash-strapped European governments may balk at funding the drug through their public healthcare systems.

Doug Brown, Head of Biomedical Research at U.K. charity MS Society said that while Lemtrada’s results are great news for patients, the drug would only be useful to them if it were available through the country’s publicly funded National Health Service.

“We urge Genzyme to price the treatment responsibly so that if it’s licensed, it’s deemed cost effective on the NHS,” he said.

The U.K.’s cost-effectiveness body National Institute for Health and Clinical Excellence (NICE), whose opinions are also watched closely in other countries, initially rejected Novartis’ MS pill Gilenya, only to make a U-turn after the company agreed to a discounted price.

Sanofi launched its MS pill Aubagio in the U.S. at a price of $ 45,000 for a year’s treatment, making it cheaper than rivals.

Gilenya – the only other MS pill currently on the market – costs 28 percent more, while injectable treatments such as Biogen Idec Inc’s Avonex and Teva Pharmaceutical Industries Ltd’s Copaxone are 8 and 6.5 percent higher respectively.

(Reporting by Elena Berton; Editing by Tim Dobbyn)

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With Christie, Obama vows, ‘We will not quit until this is done’

President Barack Obama hugs North Point Marina owner Donna Vanzant as he tours the damage in Brigantine, N.J. At …Just six days before the election, President Barack Obama toured storm-ravaged areas with New Jersey Gov. Chris Christie. He told Garden State residents struggling in the superstorm's aftermath that all of America shares their pain—and their government is there to help.

"The main message I wanted to send is the entire country has been watching what's been happening," Obama said Wednesday during a visit to the Brigantine Beach Community Center. "Everybody knows how hard Jersey's been hit."

("Except my boss," shouted Michael Henshaw, 32, a Brigantine resident who works at an insurance company. "Well, except your boss. If you need me to call, you let me know," Obama replied, drawing laughter from the room. That exchange, and many of the details in this post, are from pool reporter Reid Epstein of Politico.)

The White House told reporters that during the worst of the storm's devastation 200 people were sleeping in the center's gym, though that number has dropped to 50. The center still serves as a spot for people to get meals and take hot showers.

Obama traveled to New Jersey, which bore the brunt of the storm's wrath, with Federal Emergency Management Agency chief Craig Fugate. The president and Christie—an outspoken Mitt Romney backer—traded praise over the response to the devastating storm.

"I want to just let you know that your governor is working overtime to make sure that as soon as possible everybody can get back to normal," said Obama. "We are going to be here for the long haul. We're going to not tolerate any red tape. We're not going to tolerate any bureaucracy."

Christie, wearing a blue polar fleece jacket with "CHRIS CHRISTIE GOVERNOR" in white letters over his heart, echoed Obama's message.

"I just want to tell all of you exactly what the president just said. I know he means it," Christie said. "I want to thank the president for coming here today. It's really important to have the president of the United States acknowledge all the suffering that's going on here in New Jersey, and I appreciate it very much. We're going to work together to make sure we get ourselves through this crisis and get everything back to normal. Thank you for coming, sir."President Barack Obama and New Jersey Gov. Chris Christie (Pablo Martinez Monsivais/AP)

Aides say the president is focused on doing his job, not on the election, but the governor's praise and the seemingly smooth federal response to the storm could help him in his neck-and-neck race with Romney.

Obama and Christie took an aerial tour of some of the destruction aboard the president's Marine One helicopter before the visit to Brigantine.

In brief public remarks afterward, the governor had said of the president, "He has sprung into action immediately to help. He has worked incredibly closely with me since before the storm hit.

"It's been a great working relationship to make sure that we're doing the jobs that people elected us to do, and I cannot thank the president enough for his personal concern and compassion for our state and the people of our state."

(He also joked about those who ignored his "admonition to get the hell out of here. You are forgiven this time, but not for much longer.")

Obama returned the praise, saying Christie had been "responsive" and "aggressive" even before "this incredible storm. ... The people of New Jersey recognize that he has put his heart and soul into making sure that the people of New Jersey bounce back even stronger than before. So I just want to thank him for his extraordinary leadership and partnership."

The president added that "because of some good preparation, the loss of life was kept lower than it might have been."

He then offered his "thoughts and prayers" to those who lost loved ones. "I speak for the whole country," he said.

Both men cited the urgent need to restore power to the vast areas that lost it during the storm.

Obama, who canceled campaign events on Monday, Tuesday and Wednesday to take charge of the federal response, said he had instituted a "15-minute rule" for returning telephone calls from governors and mayors. "If they need something, we'll figure out a way to say 'yes,'" the president said.

"We will not quit until this is done," he promised.

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Hurricane’s death toll rises to 65 in Caribbean

PORT-AU-PRINCE, Haiti (AP) — As Americans braced Sunday for Hurricane Sandy, Haiti was still suffering.

Officials raised the storm-related death toll across the Caribbean to 65, with 51 of those coming in Haiti, which was pelted by three days of constant rains that ended only on Friday.

As the rains stopped and rivers began to recede, authorities were getting a fuller idea of how much damage Sandy brought on Haiti. Bridges collapsed. Banana crops were ruined. Homes were underwater. Officials said the death toll might still rise.

“This is a disaster of major proportions,” Prime Minister Laurent Lamothe told The Associated Press, adding with a touch of hyperbole, “The whole south is under water.”

The country’s ramshackle housing and denuded hillsides are especially vulnerable to flooding. The bulk of the deaths were in the southern part of the country and the area around Port-au-Prince, the capital, which holds most of the 370,000 Haitians who are still living in flimsy shelters as a result of the devastating 2010 earthquake.

Santos Alexis, mayor of the southern city of Leogane, said Sunday that the rivers were receding and that people were beginning to dry their belongings in the sun.

“Things are back to being a little quiet,” Alexis said by telephone. “We have seen the end.”

Sandy also killed 11 in Cuba, where officials said it destroyed or damaged tens of thousands of houses. Deaths were also reported in Jamaica, the Bahamas and Puerto Rico. Authorities in the Dominican Republic said the storm destroyed several bridges and isolated at least 130 communities while damaging an estimated 3,500 homes.

Jamaica’s emergency management office on Sunday was airlifting supplies to marooned communities in remote areas of four badly impacted parishes.

In the Bahamas, Wolf Seyfert, operations director at local airline Western Air, said the domestic terminal of Grand Bahamas‘ airport received “substantial damage” from Sandy’s battering storm surge and would need to be rebuilt.

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Hurricane Sandy disrupts Northeast U.S. telecom networks

NEW YORK (Reuters) - Power outages and flooding caused by Hurricane Sandy disrupted telecommunications services in Northeastern states on Tuesday, resulting in spotty coverage for cellphones, television, home telephones and Internet services.

While all the region's telecom service providers were having problems, Verizon Communications, which serves many of the states in the hurricane's path, may have suffered some of the worst damage from the storm to its wireline network.

About 25 percent of the region's wireless cell towers were out of action after the storm and some 911 emergency call centers were not working, according to Julius Genachowski, chairman of the Federal Communications Commission.

"Our assumption is that communications outages could get worse before they get better," Genachowski told reporters on a conference call, noting that the storm had not ended.

Also power outages could disrupt more cell sites if they run out of back-up power before commercial electricity services are up and running again.

People lined up at pay-phones in at least one New York neighborhood, the Lower East Side, today as their phones had either lost coverage or they had run out of battery power because there was nowhere to charge their phones in the neighborhood which had lost commercial power.

New York-based Verizon said the storm caused flooding at three Verizon central offices that hold telecom equipment in Lower Manhattan as well as sites in Queens and Long Island.

Its downtown headquarters, which was put out of action 11 years ago by the September 11 attacks, had three feet of water in the lobby at one point. Because of flooding, all its telecom equipment at that office, which serves much of Wall Street and downtown consumers, was knocked out of service.

The company said it was working on pumping out the water in the hope that it could restart its back-up power generators in the facility as commercial power services were not yet restored the morning after the big storm hit.

"The bullseye of the impact is the metro area," said spokesman William Kula, adding that restoring service for the city's financial district was a top priority for Verizon.

Telecom disruptions affect electronic trading as well as corporate operators. The chief operating officer of the New York Stock Exchange, which is expected to open Wednesday, said "lots of telecom infrastructure is down" and that the NYSE was working with big firms to ensure they were doing testing of their systems.

Verizon did not give an estimate as to how many businesses and consumers were affected. Two of three Manhattan central offices were partially flooded and operating minimal services.

Customers served by the damaged central offices will experience "a loss of all services" including TV, Internet, and traditional telephone services, Kula said. Some customers may experience intermittent busy signals for non-emergency calls.

Verizon said its engineers were working on assessing the damage from the early hours. Outside of New York, the company warned that it was also having some trouble.

"Verizon is discovering that many poles and power lines/Verizon cables are down throughout the region due to heavy winds and falling trees," the company said in a statement.

Verizon Wireless, AT&T Inc, Sprint Nextel, and T-Mobile USA said they were dealing with wireless service problems in the hurricane region. Cable operators Cablevision Systems Corp, Comcast Corp and Time Warner Cable also said they were having service problems.

"I think everybody's equipment's going to be damaged, including cellphone towers," Stifel Nicolaus analyst Christopher King said from his Verizon Wireless cellphone in Baltimore.

"Particularly for Verizon, they're clearly going to have the most damage on the wireline side because its pretty much all of their territory (where the storm hit)," King said.

Sprint Nextel, the No. 3 U.S. mobile provider said it was seeing outages at some cell sites because of the power outages across all the states in Sandy's path including New York, New Jersey, Connecticut, Pennsylvania, Washington DC, Maryland, North Virginia and New England.

"(Repair crews) have started on some critical areas but they haven't been able to get to everywhere they need to be," spokeswoman Crystal Davis said. She noted that 80 of the company's stores would reopen at noon. Sprint had closed about 180 stores ahead of the storm.

T-Mobile USA said that "customers may be experiencing service disruptions or an inability to access service in some areas, especially those that were hardest hit by the storm."

People complained of outages to their cable telephone, Internet and television services from providers including Comcast, Cablevision and Verizon in New Jersey, Connecticut, and New York.

Cablevision said it was experiencing widespread service interruptions primarily related to loss of power. The company said it is working to restore services.

Comcast, whose headquarters is in Philadelphia and serves East Coast states, said that for the majority of customers, "Comcast service should be restored as power comes back on to their homes."

Cellphone service was spotty for top wireless providers Verizon Wireless, AT&T Inc and T-Mobile USA, a unit of Deutsche Telekom, according to some customers.

Verizon Wireless, a venture of Verizon Communications and Vodafone Group, said on Tuesday afternoon that customers may be experiencing service issues and that about 94 percent of its cell sites were up and running.

AT&T said it was experiencing some issues in areas heavily affected by the storm. By Tuesday morning, spokesman Mark Siegel said AT&T was in the initial stages of on-the-ground assessment and that it expected "crews will be working around the clock to restore service."

Several Time Warner Cable customers in Brooklyn said that their Internet, television and phone services stopped working Monday night but were back again by Tuesday morning.

Time Warner Cable said that while it has not seen any major damage to its infrastructure, its customers who do not have electricity do not have cable services.

Millions of people in the eastern United States awoke on Tuesday to flooded homes, fallen trees and widespread power outages caused by Sandy, which swamped New York City's subway system and submerged streets in Manhattan's financial district.

At least 30 people were reported killed in the United States by one of the biggest storms to ever hit the country. Sandy dropped just below hurricane status before making landfall on Monday night in New Jersey.

(Additional reporting by Jennifer Saba, Liana Baker, Katya Wachtel in New York, Dian Bartz in Washington DC and many other Reuters reporters around the hurricane region; Editing by Chizu Nomiyama and Andrea Ricci)

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NBC sets premiere dates for “1600 Penn,” Eva Longoria series

LOS ANGELES, Oct 30 (TheWrap.com) – NBC announced midseason premiere dates Tuesday for three new series, including the Bill Pullman presidential comedy “1600 Penn” and the new Eva Longoria relationship series “Ready for Love.”

The network also announced the premiere date for the drama “Deception,” which was formerly known as “Infamous.”

In addition to the series premieres, the network announced return dates for several shows, including the on-the-bubble comedy “Community,” which will return to its previous Thursday night timeslot.

“Deception,” a dark family mystery starring Meagan Good and Victor Garber, premieres on Monday, January 7 at 10 p.m. It will follow “The Biggest Loser,” which starts its new season with a two-night premiere on January 6 and 7.

“1600 Penn,” starring Bill Pullman as the president in a comedy about the First Family, premieres Thursday, January 10 at 9:30. The series, which also stars Jenna Elfman and Josh Gad, was co-created by “Modern Family” director Jason Winer. It will join a slightly altered Thursday lineup.

“Parks and Recreation” moves to 8:30 on January 17, and “Community,” returns to 8 p.m. on February 7.

“Ready for Love,” a reality show executive produced by former “Desperate Housewives” star Eva Longoria, will premiere Sunday, March 31 at 8 p.m.

(Editing By Zorianna Kit)

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¿Las demandas por los efectos adversos de Neurontin aumentan el gasto en salud?

NUEVA YORK (Reuters Health) – En el 2004, el laboratorio

Pfizer aceptó declararse culpable y pagar más de 430 millones de

dólares por la acusación de haber comercializado el

antiepiléptico Neurontin ilegalmente para usos no aprobados.

Ahora, un estudio publicado en Journal of Clinical Psychiatry

cuestiona si el juicio terminó aumentando el gasto en otros

antiepilépticos en lugar de reducir los usos sin aprobación.

Los médicos pueden recetar fármacos con usos no autorizados

por las autoridades regulatorias de Estados Unidos, pero la

industria tiene prohibido comercializarlos con esos fines.

“En los últimos años hubo juicios importantes para penalizar

a las empresas farmacéuticas por la promoción ilegal de usos no

aprobados”, dijo Meredith Chace, investigadora especializada en

políticas farmacéuticas de la Facultad de Medicina de Harvard,

Boston. “Sospechábamos que eso podía tener consecuencias no

intencionales.”

Con su equipo analizó información del período 2001-2005 de

los seguros de salud federales Medicare y Medicaid. Se

concentraron en el tratamiento del trastorno bipolar, uno de los

distintos usos sin aprobar de Neurontin (gabapentina).

Desde la primera noticia publicada sobre el juicio en marzo

del 2002, la participación de Neurontin en el mercado de los

antiepilépticos que se utilizan para tratar el trastorno bipolar

se redujo del 21 al 15 por ciento.

En tanto, se disparó o siguió creciendo ese uso sin

aprobación de otros cuatro fármacos (uno de ellos aprobado más

adelante). Hasta el gasto en Neurontin aumentó, a pesar de que

se redujo su indicación.

“Desafortunadamente, el estudio sugiere que los médicos

siguieron indicando medicamentos sin efectividad probada para el

tratamiento del trastorno bipolar”, dijo el doctor Daniel

Carlat, psiquiatra y director del Proyecto Pew de Indicaciones

Médicas, que promueve políticas para limitar las relaciones

entre los médicos y la industria que afecten la atención de los

pacientes.

¿NO TAN DAÑINO COMO SE ESPERABA?

El nuevo estudio detalla que en el 2000, dos años antes de

que se conocieran las noticias sobre el juicio, las ventas de

Neurontin eran de casi 1.000 millones de dólares, principalmente

por sus usos no autorizados. Chace opinó que la cobertura

negativa de los medios influyó en parte en la caída de las

ventas de Neurontin y que es posible que el fabricante

aumentara los precios para anticiparse.

El equipo estima que el gasto gubernamental en

antiepilépticos para el tratamiento del trastorno bipolar

aumentó en más de 200 millones de dólares después del juicio,

sin incluir los potenciales cambios de indicaciones del mismo

producto para otras enfermedades, como la migraña, el síndrome

de piernas inquietas y distintos trastornos asociados con el

dolor.

“Las consecuencias no esperadas incluyen la sustitución de

otros productos similares y un aumento del gasto general”, dijo

Chace a Reuters Health.

Agregó que los ensayos clínicos habían demostrado que

Neurontin no es efectivo para el tratamiento del trastorno

bipolar, aunque con algunas excepciones.

Una limitación del estudio es no haber incluido información

sobre la inversión de la industria en la comercialización de sus

productos. Además, el cargo de Carlat está parcialmente

financiado con un subsidio que surgió del arreglo comercial de

la demanda contra Pfizer.

“Se desconoce si el juicio fue la causa del aumento de la

indicación de antiepilépticos y, por lo tanto, del gasto en

salud -dijo Carlat por e-mail-. El estudio no controló los

efectos de otros factores en las decisiones médicas, como la

estrategia de comercialización de otros productores de

antiepilépticos y la información científica de la efectividad de

otros fármacos.”

El doctor Randall S. Stafford, que no participó del estudio,

opinó sobre la posibilidad de que el juicio “no haya dañado a

Pfizer tanto como se esperaba”. Dijo por e-mail que “se estaba

venciendo la patente de Neurontin y el juicio sólo aceleró el

cambio deseado al uso sin aprobar de Lyrica”, un antiepiléptico

(pregabalina) que aún conserva su patente y fue motivo de otro

juicio similar contra Pfizer, que aceptó un convenio por 2.300

millones de dólares en el 2009.

Pfizer no realizó comentarios sobre resultados asociados “con

un acuerdo de hace una década”.

Chace consideró que las autoridades deberían trabajar con las

asociaciones médicas para informar a los profesionales sobre

estas crisis para que actúen adecuadamente.

FUENTE: Journal of Clinical Psychiatry, online 16 de octubre

del 2012

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Dozens killed, millions without power in Sandy's wake

PITTSBURGH (AP) — The most devastating storm in decades to hit the country's most densely populated region upended man and nature as it rolled back the clock on 21st-century lives, cutting off modern communication and leaving millions without power Tuesday as thousands who fled their water-menaced homes wondered when — if — life would return to normal.

A weakening Sandy, the hurricane turned fearsome superstorm, killed at least 48 people, many hit by falling trees, and still wasn't finished. It inched inland across Pennsylvania, ready to bank toward western New York to dump more of its water and likely cause more havoc Tuesday night.  Behind it: a dazed, inundated New York City, a waterlogged Atlantic Coast and a moonscape of disarray and debris — from unmoored shore-town boardwalks to submerged mass-transit systems to delicate presidential politics.

"Nature," said New York City Mayor Michael Bloomberg, assessing the damage to his city, "is an awful lot more powerful than we are."

More than 8.2 million households were without power in 17 states as far west as Michigan. Nearly 2 million of those were in New York, where large swaths of lower Manhattan lost electricity and entire streets ended up under water — as did seven subway tunnels between Manhattan and Brooklyn at one point, the Metropolitan Transportation Authority said. The New York Stock Exchange was closed for a second day from weather, the first time that has happened since a blizzard in 1888. The city's subway system, the lifeblood of more than 5 million residents, was damaged like never before and closed indefinitely, and Consolidated Edison said electricity in and around New York could take a week to restore.

"Everybody knew it was coming. Unfortunately, it was everything they said it was," said Sal Novello, a construction executive who rode out the storm with his wife, Lori, in the Long Island town of Lindenhurst, and ended up with 7 feet of water in the basement.

Photos: Superstorm Sandy wreaks havoc

1. 
   
   

The scope of the storm's damage wasn't known yet. Though early predictions of river flooding in Sandy's inland path were petering out, colder temperatures made snow the main product of Sandy's slow march from the sea. Parts of the West Virginia mountains were blanketed with 2 feet of snow by Tuesday afternoon, and drifts 4 feet deep were reported at Great Smoky Mountains National Park on the Tennessee-North Carolina border.

With Election Day a week away, the storm also threatened to affect the presidential campaign. Federal disaster response, always a dicey political issue, has become even thornier since government mismanagement of Hurricane Katrina in 2005. And poll access and voter turnout, both of which hinge upon how people are impacted by the storm, could help shift the outcome in an extremely close race.

As organized civilization came roaring back Tuesday in the form of emergency response, recharged cellphones and the reassurance of daylight, harrowing stories and pastiches emerged from Maryland north to Rhode Island in the hours after Sandy's howling winds and tidal surges shoved water over seaside barriers, into low-lying streets and up from coastal storm drains.

Images from around the storm-affected areas depicted scenes reminiscent of big-budget disaster movies. In Atlantic City, N.J., a gaping hole remained where once a stretch of boardwalk sat by the sea. In Queens, N.Y., rubble from a fire that destroyed as many as 100 houses in an evacuated beachfront neighborhood jutted into the air at ugly angles against a gray sky. In heavily flooded Hoboken, N.J., across the Hudson River from Manhattan, dozens of yellow cabs sat parked in rows, submerged in murky water to their windshields. At the ground zero construction site in lower Manhattan, sea water rushed into a gaping hole under harsh floodlights.

One of the most dramatic tales came from lower Manhattan, where a failed backup generator forced New York University's Tisch Hospital to relocate more than 200 patients, including 20 babies from neonatal intensive care. Dozens of ambulances lined up in the rainy night and the tiny patients were gingerly moved out, some attached to battery-powered respirators as gusts of wind blew their blankets.

In Moonachie, N.J., 10 miles north of Manhattan, water rose to 5 feet within 45 minutes and trapped residents who thought the worst of the storm had passed. Mobile-home park resident Juan Allen said water overflowed a 2-foot wall along a nearby creek, filling the area with 2 to 3 feet of water within 15 minutes. "I saw trees not just knocked down but ripped right out of the ground," he said. "I watched a tree crush a guy's house like a wet sponge."

In a measure of its massive size, waves on southern Lake Michigan rose to a record-tying 20.3 feet. High winds spinning off Sandy's edges clobbered the Cleveland area early Tuesday, uprooting trees, closing schools and flooding major roads along Lake Erie.

Most along the East Coast, though, grappled with an experience like Bertha Weismann of Bridgeport, Conn.— frightening, inconvenient and financially problematic but, overall, endurable. Her garage was flooded and she lost power, but she was grateful. "I feel like we are blessed," she said. "It could have been worse."

The presidential candidates' campaign maneuverings Tuesday revealed the delicacy of the need to look presidential in a crisis without appearing to capitalize on a disaster. President Barack Obama canceled a third straight day of campaigning, scratching events scheduled for Wednesday in swing-state Ohio, in Sandy's path. Republican Mitt Romney resumed his campaign with plans for an Ohio rally billed as a "storm relief event."

And the weather posed challenges a week out for how to get everyone out to vote. On the hard-hit New Jersey coastline, a county elections chief said some polling places on barrier islands will be unusable and have to be moved.

 "This is the biggest challenge we've ever had," said George R. Gilmore, chairman of the Ocean County Board of Elections.

By Tuesday afternoon, there were still only hints of the economic impact of the storm. Airports remained closed across the East Coast and far beyond as tens of thousands of travelers found they couldn't get where they were going.

Forecasting firm IHS Global Insight predicted the storm will end up causing about $20 billion in damages and $10 billion to $30 billion in lost business. Another firm, AIR Worldwide, estimated losses up to $15 billion — big numbers probably offset by reconstruction and repairs that will contribute to longer-term growth.

"The biggest problem is not the first few days but the coming months," said Alan Rubin, an expert in nature disaster recovery.

Sandy began in the Atlantic and knocked around the Caribbean — killing nearly 70 people — and strengthened into a hurricane as it chugged across the southeastern coast of the United States. By Tuesday night it had ebbed in strength but was joining up with another, more wintry storm — an expected confluence of weather systems that earned it nicknames like "superstorm" and, on Halloween eve, "Frankenstorm."

It became, pretty much everyone agreed Tuesday, the weather event of a lifetime — and one shared vigorously on social media by people in Sandy's path who took eye-popping photographs as the storm blew through, then shared them with the world by the blue light of their smartphones. 

On Twitter , Facebook and the photo-sharing service Instagram, people tried to connect, reassure relatives and make sense of what was happening — and, in many cases, work to authenticate reports of destruction and storm surges. They posted and passed around images and real-time updates at a dizzying rate, wishing each other well and gaping, virtually, at scenes of calamity moments after they unfolded. Among the top terms on Facebook through the night and well into Tuesday, according to the social network: "we are OK," ''made it" and "fine."

Around midday Tuesday, Sandy was about 120 miles east of Pittsburgh, pushing westward with winds of 45 mph, and was expected to turn toward New York State on Tuesday night. Although weakening as it goes, the storm will continue to bring heavy rain and flooding, said Daniel Brown of the National Hurricane Center in Miami.

Atlantic City's fabled Boardwalk, the first in the nation, lost several blocks when Sandy came through, though the majority of it remained intact even as other Jersey Shore boardwalks were dismantled. What damage could be seen on the coastline Tuesday was, in some locations, staggering — "unthinkable," New Jersey Gov. Chris Christie said of what unfolded along the Jersey Shore, where houses were swept from their foundations and amusement park rides were washed into the ocean. "Beyond anything I thought I would ever see."

Resident Carol Mason returned to her bayfront home to carpets that squished as she stepped on them. She made her final mortgage payment just last week. Facing a mandatory evacuation order, she had tried to ride out the storm at first but then saw the waters rising outside her bathroom window and quickly reconsidered.

"I looked at the bay and saw the fury in it," she said. "I knew it was time to go."

___

Contributing to this report were Katie Zezima in Atlantic City, N.J.; Alicia Caldwell and Martin Crutsinger in Washington; Colleen Long, Jennifer Peltz, Tom Hays, Larry Neumeister, Ralph Russo and Scott Mayerowitz in New York; Meghan Barr in Mastic Beach, N.Y.; Christopher S. Rugaber in Arlington, Va.; Marc Levy in Harrisburg, Pa.: John Christoffersen in Bridgeport, Conn.; Vicki Smith in Elkins, W.Va.; David Porter in Newark, N.J.; Joe Mandak in Pittsburgh; and Dave Collins in Hartford, Conn.

___

Follow Ted Anthony on Twitter at http://twitter.com/anthonyted

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Pole gets 30 years for killing 6 on Channel Island

LONDON (AP) — A Polish builder who killed six people, including his wife and children, on the British Channel Island of Jersey has been sentenced to 30 years in prison.

Damian Rzeszowski, 31, carried out the knife attack in August 2011 at his home. He was said to have become depressed after his wife admitted to an affair.

Rzeszowski was convicted of six counts of manslaughter but cleared of murder. On Monday, Judge Michael Birt sentenced him to 30 years in jail for each victim, but the sentences are to run concurrently.

Rzeszowski’s victims were his wife Izabela Rzeszowska, 30; 5-year-old daughter, Kinga; 2-year-old son, Kacper; father-in-law, Marek Gartska, 56; his wife’s friend Marta De La Haye, 34; and her 5-year-old daughter, Julia.

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